Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4844178 | 0.97 | BACE1 (0.35) | BACE1ALDH1A1MAPTHPGDRAB9A | |
| Hydrochloric Acid SCHEMBL5244680 | 0.96 | BACE1 (0.35) | BACE1ALDH1A1MAPTHPGDRAB9A | |
| Hydrochloric Acid SCHEMBL4843547 | 0.87 | MAPT (0.35) | BACE1ALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL4836633 | 0.84 | MAPT (0.34) | BACE1ALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL6994128 | 0.84 | IDO1 (0.34) | BACE1ALDH1A1MAPTHPGDRAB9A | |
| Hydrochloric Acid SCHEMBL4843411 | 0.83 | IDO1 (0.33) | BACE1ALDH1A1MAPTHPGDRAB9A | |
| Hydrochloric Acid SCHEMBL4843553 | 0.83 | MAPT (0.34) | BACE1ALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL14156629 | 0.80 | LMNA (0.36) | BACE1ALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL14156683 | 0.80 | KIF11 (0.36) | BACE1 | |
| Hydrochloric Acid SCHEMBL4836312 | 0.79 | LMNA (0.35) | BACE1ALDH1A1MAPTHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546134-B1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | LILLY CO ELI (US) | 2007-05-02 | — | — | EP | disclosed |