Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GSTP1 | P09211 | 5/20 | 0.50 |
| ▸ | GSTM2 | P28161 | 5/20 | 0.50 |
| ▸ | MYC | P01106 | 4/20 | 0.50 |
| ▸ | IDO1 | P14902 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.45 |
| ▸ | MAX | P61244 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243500 | 0.85 | MEN1 (0.64) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL4787872 | 0.82 | IDO1 (0.53) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL5281251 | 0.81 | MEN1 (0.51) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL4785470 | 0.80 | IDO1 (0.53) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL4787667 | 0.79 | MEN1 (0.63) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL5243642 | 0.79 | MYC (0.67) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL4787990 | 0.77 | ARNT (0.47) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL5243120 | 0.76 | KMT2A (0.52) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL4784084 | 0.75 | IDO1 (0.52) | MEN1KMT2AGSTP1GSTM2MYC | |
| SCHEMBL16120142 | 0.74 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758873-A1 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | claimed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282818-A1 | Ubiquitin ligase inhibitors | NEDD4, TRAF6, XIAP | MEN1 3562/4885KMT2A 1303/4885GSTP1 2061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.