Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741365 | 0.87 | ALOX15 (0.65) | KDM4EALOX15TSHRSIRT1ACHE | |
| SCHEMBL29427924 | 0.87 | ALOX15 (0.65) | KDM4EALOX15TSHRSIRT1ACHE | |
| SCHEMBL25330979 | 0.86 | NPC1 (0.57) | KDM4EALOX15TSHRSIRT1DRD2 | |
| SCHEMBL2028744 | 0.86 | KMT2A (0.58) | KDM4EALOX15TSHRSIRT1ACHE | |
| SCHEMBL2026440 | 0.85 | DAO (0.44) | KDM4EALOX15TSHRSIRT1DAO | |
| SCHEMBL2023370 | 0.85 | ALDH1A1 (0.44) | KDM4EALOX15TSHRSIRT1DAO | |
| SCHEMBL5240140 | 0.82 | DRD3 (0.58) | KDM4EALOX15TSHRSIRT1ACHE | |
| SCHEMBL5245247 | 0.81 | PARP1 (0.53) | DAOALDH1A1PARP1PARP2FFAR1 | |
| SCHEMBL2027141 | 0.81 | EGFR (0.45) | DAOHTR1ADRD2DRD5DRD3 | |
| SCHEMBL2026621 | 0.81 | EGFR (0.45) | DAOHTR1ADRD2DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |