Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | SLC26A6 | Q9BXS9 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208219 | 0.89 | SMN1; SMN2 (0.45) | KIF11SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL3901729 | 0.89 | SMN1; SMN2 (0.48) | KIF11SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL5234446 | 0.88 | BRD4 (0.42) | KIF11SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL3871568 | 0.82 | SMN1; SMN2 (0.53) | KIF11SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL3962257 | 0.79 | KIF11 (0.65) | KIF11CYP2C19 | |
| SCHEMBL5232886 | 0.79 | KIF11 (0.51) | KIF11HPGDPDE4APDE4BPDE4C | |
| SCHEMBL5246246 | 0.78 | PDE4A (0.49) | KIF11SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL4043063 | 0.78 | SMN1; SMN2 (0.44) | KIF11SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL3872559 | 0.78 | KIF11 (0.54) | KIF11SMN1; SMN2HPGDDCTPP1SLC26A6 | |
| SCHEMBL5237790 | 0.78 | SLC26A6 (0.41) | KIF11SMN1; SMN2HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | AstraZeneca AB (SE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004078758-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | disclosed |