Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5245965 | 0.94 | PDE10A (0.37) | HPGDNPC1ROCK2ROCK1EPHX2 | |
| SCHEMBL5247821 | 0.92 | ROCK2 (0.40) | ROCK2ROCK1EPHX2 | |
| SCHEMBL5244821 | 0.92 | PPARG (0.38) | ROCK2ROCK1EPHX2PDE10A | |
| SCHEMBL5244350 | 0.92 | ROCK2 (0.38) | ROCK2ROCK1LMNAPDE10A | |
| SCHEMBL5250093 | 0.91 | ROCK2 (0.41) | HPGDNPC1ROCK2ROCK1LMNA | |
| SCHEMBL5246041 | 0.90 | MIF (0.45) | EPHX2LMNA | |
| SCHEMBL5248109 | 0.88 | EGLN1 (0.38) | ROCK2ROCK1EPHX2PDE10ANAMPT | |
| SCHEMBL5245995 | 0.88 | ROCK2 (0.41) | ROCK2ROCK1EPHX2LMNAMAPT | |
| SCHEMBL5244804 | 0.88 | ROCK2 (0.39) | ROCK2ROCK1EPHX2 | |
| SCHEMBL5247824 | 0.88 | MMP13 (0.39) | ROCK2ROCK1EPHX2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867331-A1 | TRIAZOLE DERIVATIVE AND THE USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-12-19 | — | — | EP | disclosed |