Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650095 | 0.82 | FOLH1 (0.52) | FOLH1P4HTMMEN1KMT2AGABRP | |
| SCHEMBL27983120 | 0.80 | GABRP (0.48) | MAP4K4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5252361 | 0.79 | FOLH1 (0.52) | FOLH1MAP4K4P4HTMMEN1KMT2A | |
| SCHEMBL22715422 | 0.79 | FOLH1 (0.52) | FOLH1P4HTMMEN1KMT2AGABRP | |
| SCHEMBL29472138 | 0.79 | FOLH1 (0.52) | FOLH1P4HTMMEN1KMT2AGABRP | |
| Hydrochloric Acid SCHEMBL15968325 | 0.79 | GABRG2 (0.47) | MAP4K4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL22075603 | 0.77 | GABRP (0.48) | MAP4K4GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL22117010 | 0.77 | GABRG2 (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5495792 | 0.76 | MAOB (0.60) | P4HTMMEN1KMT2AMCL1NR4A2 | |
| SCHEMBL18031278 | 0.75 | FOLH1 (0.51) | FOLH1MAP4K4P4HTMPTGER1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786785-A2 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | Pfizer, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006021884-A2 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2006-03-02 | — | — | WO | disclosed |