Capromorelin

Capromorelin

SCHEMBL5246732

CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GHSR

The experimentally established mechanism targets of Capromorelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GHSR known ✓ Q92847 18/20 1.00
UGCG Q16739 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Capromorelin SCHEMBL3245235 1.00 GHSR (1.00) GHSRUGCG
Capromorelin SCHEMBL1147592 1.00 GHSR (1.00) GHSRUGCG
Capromorelin SCHEMBL14977966 1.00 GHSR (1.00) GHSRUGCG
Capromorelin SCHEMBL18804380 1.00 GHSR (1.00) GHSRUGCG
Capromorelin SCHEMBL5245758 0.99 GHSR (0.98) GHSRUGCG
Capromorelin SCHEMBL5245765 0.99 GHSR (0.98) GHSRUGCG
Capromorelin SCHEMBL5245768 0.99 GHSR (0.98) GHSRUGCG
Capromorelin SCHEMBL5253167 0.97 GHSR (0.94) GHSR
Capromorelin SCHEMBL5253173 0.97 GHSR (0.94) GHSR
Capromorelin SCHEMBL20292027 0.96 GHSR (0.93) GHSRUGCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210179613-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF CACHEXIA RAQUALIA PHARMA INC. (JP) 2021-06-17 US claimed
US-20150099709-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RAQUALIA PHARMA INC. (JP) 2015-04-09 US claimed
EP-2854810-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RaQualia Pharma Inc (JP) 2015-04-08 EP claimed
WO-2013175805-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RAQUALIA PHARMA INC. (JP) 2013-11-28 WO claimed
EP-2540721-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF DYSCRASIA RaQualia Pharma Inc (JP) 2013-01-02 EP claimed
US-20120322821-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF CACHEXIA RAQUALIA PHARMA INC. (JP) 2012-12-20 US claimed
EP-0869968-B1 GROWTH-HORMONE SECRETAGOGUES PFIZER (US) 2007-05-02 EP claimed
US-20020049196-A1 Growth-hormone secretagogues RAQUALIA PHARMA INC. (JP) 2002-04-25 US claimed
US-6107306-A OSTEOPOROSIS PFIZER INC. (US) 2000-08-22 US claimed
EP-0869968-A1 GROWTH-HORMONE SECRETAGOGUES PFIZER INC. (US) 1998-10-14 EP claimed
WO-1997024369-A1 GROWTH-HORMONE SECRETAGOGUES PFIZER INC. (US) 1997-07-10 WO claimed
US-20210179613-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF CACHEXIA RAQUALIA PHARMA INC. (JP) 2021-06-17 US disclosed
US-10975070-B2 Ghrelin receptor agonist for treatment of cachexia RAQUALIA PHARMA INC. (JP) 2021-04-13 US disclosed
US-20150099709-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RAQUALIA PHARMA INC. (JP) 2015-04-09 US disclosed
EP-2854810-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RaQualia Pharma Inc (JP) 2015-04-08 EP disclosed
US-6124264-A GROWTH HORMONE SECRETAGOGUE IN A HUMAN OR OTHER ANIMAL TO TREAT OSTEOPOROSIS, CONGESTIVE HEART FAILURE, AGING, OBESITY; BONE AND WOUND HEALING AGENTS PFIZER INC. (US) 2000-09-26 US disclosed
US-6110932-A INCREASE THE LEVEL OF ENDOGENOUS GROWTH HORMONE FOR THE TREATMENT AND PREVENTION OF OSTEOPOROSIS, CONGESTIVE HEART FAILURE, FRAILTY ASSOCIATED WITH AGING, OBESITY; ACCELERATING BONE FRACTURE REPAIR, ACCELERATING WOUND HEALING PFIZER INC. (US) 2000-08-29 US disclosed
US-6107306-A OSTEOPOROSIS PFIZER INC. (US) 2000-08-22 US disclosed
EP-0869968-A1 GROWTH-HORMONE SECRETAGOGUES PFIZER INC. (US) 1998-10-14 EP disclosed
WO-1997024369-A1 GROWTH-HORMONE SECRETAGOGUES PFIZER INC. (US) 1997-07-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150099709-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA GIPR, GHSR, GLP1R GHSR 2/4885UGCG 1246/4885
US-20120322821-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF CACHEXIA GIPR, GCGR, GHSR GHSR 3/4885UGCG 2131/4885
US-10975070-B2 Ghrelin receptor agonist for treatment of cachexia GIPR, GCGR, GHSR GHSR 3/4885UGCG 2131/4885
US-20020049196-A1 Growth-hormone secretagogues GHSR, GHRHR, IGFBP6 GHSR 1/4885UGCG 1791/4885
US-20210179613-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF CACHEXIA GIPR, GCGR, GHSR GHSR 3/4885UGCG 2131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.