SCHEMBL5247341

SCHEMBL5247341

CCCCCC(N1CCN(c2ccccc2)CC1)N1CCN(c2ccccc2)CC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.51
SIGMAR1 Q99720 1/20 0.51
CHRNA7 P36544 2/20 0.50
LMNA P02545 1/20 0.45
PLA2G1B P04054 1/20 0.45
TSHR P16473 1/20 0.45
KMT2A Q03164 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
ATG4B Q9Y4P1 1/20 0.45
KCNH2 Q12809 1/20 0.45
DPP4 P27487 2/20 0.43
KDM4E B2RXH2 2/20 0.43
ADRA2A P08913 1/20 0.43
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43
ALDH1A1 P00352 1/20 0.43
GFER P55789 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CYP2D6 P10635 1/20 0.41
DRD4 P21917 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3259353 0.89 DRD2 (0.47) DRD2SIGMAR1CHRNA7LMNAPLA2G1B
SCHEMBL11668124 0.84 DRD2 (0.49) DRD2SIGMAR1CHRNA7LMNAPLA2G1B
SCHEMBL5243181 0.84 KCNH2 (0.54) KCNH2ALDH1A1OPRM1
SCHEMBL5243158 0.83 KCNH2 (0.52) LMNATSHRNPSR1KCNH2ALDH1A1
SCHEMBL5244521 0.82 DRD2 (0.59) DRD2TSHRKMT2AKCNH2KDM4E
SCHEMBL5243910 0.78 KDM4E (0.52) KMT2ANPSR1KCNH2KDM4EALDH1A1
SCHEMBL23133806 0.77 DRD2 (0.54) DRD2SIGMAR1CHRNA7TSHRKMT2A
Hexane SCHEMBL28857999 0.75 DRD2 (0.56) DRD2SIGMAR1CHRNA7LMNAPLA2G1B
SCHEMBL8844306 0.75 DRD2 (0.53) DRD2SIGMAR1CHRNA7TSHRKMT2A
SCHEMBL7594226 0.75 KCNH2 (0.79) DRD2SIGMAR1CHRNA7LMNAKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1836192-A2 ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS Universita' Degli Studi di Siena (IT) 2007-09-26 EP claimed
WO-2006072608-A2 ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS UNIVERSITÁ DEGLI STUDI DI SIENA (IT) 2006-07-13 WO claimed
EP-1836192-A2 ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS Universita' Degli Studi di Siena (IT) 2007-09-26 EP disclosed
WO-2006072608-A2 ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS UNIVERSITÁ DEGLI STUDI DI SIENA (IT) 2006-07-13 WO disclosed