SCHEMBL5247351

SCHEMBL5247351

COC(=O)c1sccc1S(=O)(=O)N1CCCC(C(=O)NCCc2cccs2)C1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.56
GAA P10253 2/20 0.56
HTT P42858 3/20 0.56
LMNA P02545 2/20 0.54
TSHR P16473 2/20 0.54
POLB P06746 1/20 0.53
NPC1 O15118 1/20 0.52
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
MAPT P10636 2/20 0.50
ALDH1A1 P00352 2/20 0.50
RAB9A P51151 1/20 0.50
ATM Q13315 1/20 0.50
NPSR1 Q6W5P4 2/20 0.49
SMN1; SMN2 Q16637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5245026 0.88 GAA (0.58) KDM4EGAAHTTLMNATSHR
SCHEMBL5244916 0.81 MAPT (0.65) HTTLMNATSHRPOLBMEN1
SCHEMBL6003634 0.77 POLB (0.47) KDM4EGAAHTTLMNATSHR
SCHEMBL22735676 0.73 THRB (0.63) KDM4EGAALMNATSHRMAPT
SCHEMBL5245564 0.72 GAA (1.00) KDM4EGAAHTTTSHRPOLB
SCHEMBL3323307 0.72 HPGD (0.74) KDM4EGAAHTTTSHRPOLB
SCHEMBL5243895 0.69 KDM4E (0.69) KDM4EGAAHTTLMNATSHR
SCHEMBL6002179 0.68 CYP19A1 (0.51) KDM4EGAAHTTLMNATSHR
SCHEMBL5248192 0.68 ATM (0.70) GAAHTTTSHRPOLBNPC1
SCHEMBL24799357 0.67 ITGB3 (0.64) KDM4EGAAHTTTSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1866285-A1 1-SULFONYL-PIPERDINE-3-CARBOXYLIC ACID AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE FOR THE TREATMENT OF TYPE II DIABETES MELLITUS F. Hoffmann-Roche AG (CH) 2007-12-19 EP claimed
WO-2006094633-A1 1- SULFONYL-PI PERDINE- 3 -CARBOXYL I C ACID AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE FOR THE TREATMENT OF TYPE II DIABETES MELLITUS F. HOFFMAN-LA ROCHE AG (CH) 2006-09-14 WO claimed
EP-1866285-A1 1-SULFONYL-PIPERDINE-3-CARBOXYLIC ACID AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE FOR THE TREATMENT OF TYPE II DIABETES MELLITUS F. Hoffmann-Roche AG (CH) 2007-12-19 EP disclosed
WO-2006094633-A1 1- SULFONYL-PI PERDINE- 3 -CARBOXYL I C ACID AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE FOR THE TREATMENT OF TYPE II DIABETES MELLITUS F. HOFFMAN-LA ROCHE AG (CH) 2006-09-14 WO disclosed