SCHEMBL5247489

SCHEMBL5247489

CN1N=C2CCN(C(=O)[C@H](CCCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O

nearest known ligand 0.76

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 11/20 0.76
NPY1R P25929 3/20 0.36
MMP1 P03956 4/20 0.35
MMP3 P08254 4/20 0.35
MMP9 P14780 3/20 0.35
CCKBR P32239 1/20 0.34
NPY2R P49146 1/20 0.33
NPY5R Q15761 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5249061 1.00 GHSR (0.76) GHSRNPY1RMMP1MMP3MMP9
SCHEMBL5246834 1.00 GHSR (0.76) GHSRNPY1RMMP1MMP3MMP9
SCHEMBL6213082 1.00 GHSR (0.76) GHSRNPY1RMMP1MMP3MMP9
SCHEMBL5246828 1.00 GHSR (0.76) GHSRNPY1RMMP1MMP3MMP9
Hydrochloric Acid SCHEMBL5249487 0.99 GHSR (0.75) GHSRNPY1RMMP1MMP3MMP9
Hydrochloric Acid SCHEMBL5248090 0.99 GHSR (0.75) GHSRNPY1RMMP1MMP3MMP9
Hydrochloric Acid SCHEMBL5248096 0.99 GHSR (0.75) GHSRNPY1RMMP1MMP3MMP9
SCHEMBL7669620 0.95 GHSR (0.79) GHSRCCKBR
SCHEMBL7669621 0.95 GHSR (0.79) GHSRCCKBR
SCHEMBL19469271 0.95 GHSR (0.79) GHSRCCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150099709-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RAQUALIA PHARMA INC. (JP) 2015-04-09 US claimed
EP-2854810-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RaQualia Pharma Inc (JP) 2015-04-08 EP claimed
WO-2013175805-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RAQUALIA PHARMA INC. (JP) 2013-11-28 WO claimed
EP-0869968-B1 GROWTH-HORMONE SECRETAGOGUES PFIZER (US) 2007-05-02 EP claimed
US-20020049196-A1 Growth-hormone secretagogues RAQUALIA PHARMA INC. (JP) 2002-04-25 US claimed
US-6107306-A OSTEOPOROSIS PFIZER INC. (US) 2000-08-22 US claimed
EP-0869968-A1 GROWTH-HORMONE SECRETAGOGUES PFIZER INC. (US) 1998-10-14 EP claimed
WO-1997024369-A1 GROWTH-HORMONE SECRETAGOGUES PFIZER INC. (US) 1997-07-10 WO claimed
US-20210179613-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF CACHEXIA RAQUALIA PHARMA INC. (JP) 2021-06-17 US disclosed
US-10975070-B2 Ghrelin receptor agonist for treatment of cachexia RAQUALIA PHARMA INC. (JP) 2021-04-13 US disclosed
US-20150099709-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RAQUALIA PHARMA INC. (JP) 2015-04-09 US disclosed
EP-2854810-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RaQualia Pharma Inc (JP) 2015-04-08 EP disclosed
WO-2013175805-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA RAQUALIA PHARMA INC. (JP) 2013-11-28 WO disclosed
EP-2540721-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF DYSCRASIA RaQualia Pharma Inc (JP) 2013-01-02 EP disclosed
US-6313140-B1 ADMINISTERING TO A HUMAN OR OTHER ANIMAL PYRAZOLOPYRIMIDINE DERIVATIVE FOR PROPHYLAXIS OR THERAPY OF DISEASE OR CONDITION WHICH MAY BE TREATED OR PREVENTED BY GROWTH HORMONE PFIZER INC. 2001-11-06 US disclosed
US-6306875-B1 ADMINISTERING GROWTH HORMONES DIPEPTIDE COMPOUNDS WHICH ARE GROWTH HORMONE SECRETAGOGUES AND ARE USEFUL FOR THE TREATMENT AND PREVENTION OF OSTEOPOROSIS. PFIZER INC. 2001-10-23 US disclosed
US-6278000-B1 INCREASE LEVEL OF ENDOGENOUS GROWTH HORMONE; USEFUL IN THERAPY AND PROPHYLAXIS OF OSTEOPOROSIS, CONGESTIVE HEART FAILURE, FRAILTY ASSOCIATED WITH AGING AND OBESITY, ACCELERATING BONE FRACTURE REPAIR PFIZER INC. 2001-08-21 US disclosed
US-6124264-A GROWTH HORMONE SECRETAGOGUE IN A HUMAN OR OTHER ANIMAL TO TREAT OSTEOPOROSIS, CONGESTIVE HEART FAILURE, AGING, OBESITY; BONE AND WOUND HEALING AGENTS PFIZER INC. (US) 2000-09-26 US disclosed
US-6110932-A INCREASE THE LEVEL OF ENDOGENOUS GROWTH HORMONE FOR THE TREATMENT AND PREVENTION OF OSTEOPOROSIS, CONGESTIVE HEART FAILURE, FRAILTY ASSOCIATED WITH AGING, OBESITY; ACCELERATING BONE FRACTURE REPAIR, ACCELERATING WOUND HEALING PFIZER INC. (US) 2000-08-29 US disclosed
US-6107306-A OSTEOPOROSIS PFIZER INC. (US) 2000-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150099709-A1 GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA GIPR, GHSR, GLP1R GHSR 2/4885NPY1R 33/4885MMP1 3574/4885
US-10975070-B2 Ghrelin receptor agonist for treatment of cachexia GIPR, GCGR, GHSR GHSR 3/4885NPY1R 52/4885MMP1 3914/4885
US-20020049196-A1 Growth-hormone secretagogues GHSR, GHRHR, IGFBP6 GHSR 1/4885NPY1R 41/4885MMP1 980/4885
US-20210179613-A1 GHRELIN RECEPTOR AGONIST FOR TREATMENT OF CACHEXIA GIPR, GCGR, GHSR GHSR 3/4885NPY1R 52/4885MMP1 3914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.