Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4832631 | 0.99 | TACR1 (0.51) | TACR1NAMPTCYP3A4LMNATSHR | |
| SCHEMBL5247333 | 0.94 | TACR1 (0.58) | TACR1CCR2MTOR | |
| Hydrochloric Acid SCHEMBL4837314 | 0.93 | TACR1 (0.57) | TACR1CCR2MTOR | |
| SCHEMBL4834954 | 0.91 | METAP2 (0.47) | TACR1 | |
| Hydrochloric Acid SCHEMBL4836273 | 0.90 | METAP2 (0.47) | TACR1 | |
| SCHEMBL5248595 | 0.88 | TACR1 (0.47) | TACR1NAMPTMTOR | |
| Hydrochloric Acid SCHEMBL4832298 | 0.87 | TACR1 (0.46) | TACR1NAMPTMTOR | |
| SCHEMBL5247345 | 0.86 | METAP2 (0.52) | — | |
| Hydrochloric Acid SCHEMBL4837577 | 0.85 | METAP2 (0.51) | — | |
| SCHEMBL5246557 | 0.84 | NPC1 (0.48) | LMNATSHRALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1707564-B1 | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2007-09-12 | — | — | EP | disclosed |
| EP-1707564-A2 | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2006-10-04 | — | — | EP | disclosed |