Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4832298 | 0.99 | TACR1 (0.46) | TACR1CHRM3NAMPTMC4RMMP8 | |
| SCHEMBL5247333 | 0.91 | TACR1 (0.58) | TACR1CHRM3MTOR | |
| Hydrochloric Acid SCHEMBL4837314 | 0.90 | TACR1 (0.57) | TACR1CHRM3MTOR | |
| SCHEMBL5246174 | 0.88 | MMP8 (0.53) | TACR1NAMPTMC4RMMP8 | |
| SCHEMBL5247733 | 0.88 | TACR1 (0.52) | TACR1NAMPTMTOR | |
| SCHEMBL5246557 | 0.87 | NPC1 (0.48) | MMP8 | |
| Hydrochloric Acid SCHEMBL4834764 | 0.87 | MMP8 (0.52) | TACR1NAMPTMC4RMMP8 | |
| Hydrochloric Acid SCHEMBL4832631 | 0.87 | TACR1 (0.51) | TACR1NAMPTMTOR | |
| Hydrochloric Acid SCHEMBL4830172 | 0.86 | KMT2A (0.47) | MMP8 | |
| SCHEMBL5245143 | 0.85 | MMP8 (0.47) | NAMPTMMP8MAPK10CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1707564-B1 | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2007-09-12 | — | — | EP | disclosed |
| EP-1707564-A2 | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2006-10-04 | — | — | EP | disclosed |