Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4830172 | 0.99 | KMT2A (0.47) | NPC1KMT2AMEN1MMP8RAB9A | |
| SCHEMBL5246174 | 0.91 | MMP8 (0.53) | KMT2AMEN1MMP8ALDH1A1SMN1; SMN2 | |
| SCHEMBL4834954 | 0.91 | METAP2 (0.47) | NPC1KMT2AMEN1MMP8 | |
| Hydrochloric Acid SCHEMBL4834764 | 0.90 | MMP8 (0.52) | KMT2AMEN1MMP8ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4836273 | 0.90 | METAP2 (0.47) | NPC1KMT2AMEN1MMP8 | |
| SCHEMBL5246115 | 0.88 | MMP8 (0.47) | KMT2AMEN1MMP8ALDH1A1LMNA | |
| SCHEMBL5245143 | 0.88 | MMP8 (0.47) | NPC1KMT2AMEN1MMP8RAB9A | |
| SCHEMBL5244674 | 0.88 | KMT2A (0.48) | KMT2AMEN1MMP8POLBALDH1A1 | |
| SCHEMBL5248547 | 0.88 | SMN1; SMN2 (0.48) | NPC1KMT2AMEN1MMP8RAB9A | |
| SCHEMBL5248595 | 0.87 | TACR1 (0.47) | MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1707564-B1 | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2007-09-12 | — | — | EP | disclosed |
| EP-1707564-A2 | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2006-10-04 | — | — | EP | disclosed |