Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CSF1R | P07333 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247652 | 0.88 | MAPT (0.47) | MAPTLMNAHTTCA1CA2 | |
| SCHEMBL5244451 | 0.86 | MAPT (0.58) | MAPTLMNAHTTMEN1KMT2A | |
| SCHEMBL2019674 | 0.84 | CA1 (0.43) | MAPTLMNAHTTCA1CA2 | |
| SCHEMBL17815794 | 0.83 | MAPT (0.43) | MAPTLMNAHTTCA1CA2 | |
| SCHEMBL17815790 | 0.82 | PRMT1 (0.43) | MAPTLMNAHTTCA1CA2 | |
| SCHEMBL8078419 | 0.78 | LMNA (0.40) | MAPTLMNAHTTCA1CA2 | |
| SCHEMBL5248227 | 0.76 | EGFR (0.38) | LMNAHTTMEN1KMT2ACSF1R | |
| SCHEMBL6662120 | 0.73 | HTT (0.40) | MAPTLMNAHTTCA1CA2 | |
| SCHEMBL9124007 | 0.71 | ALDH1A1 (0.40) | MAPTLMNAHTTCA1CA2 | |
| SCHEMBL304909 | 0.70 | CA1 (0.49) | MAPTLMNAHTTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848506-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | Attenuon, LLC (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089298-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | ATTENUON, LLC (US) | 2006-08-24 | — | — | WO | disclosed |