Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 8/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.76 |
| ▸ | PIM1 | P11309 | 6/20 | 0.66 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MMP3 | P08254 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248357 | 1.00 | ADAMTS5 (1.00) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL5154109 | 0.90 | ADAMTS5 (0.81) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL5154117 | 0.90 | ADAMTS5 (0.81) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL8171910 | 0.89 | ADAMTS5 (0.80) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL8171912 | 0.89 | ADAMTS5 (0.80) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL8188463 | 0.89 | ADAMTS5 (1.00) | ADAMTS5AKR1B1MMP3MMP13CISD1 | |
| SCHEMBL7972291 | 0.89 | ADAMTS5 (1.00) | ADAMTS5AKR1B1MMP3MMP13CISD1 | |
| SCHEMBL1247917 | 0.87 | AKR1B1 (0.81) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL12891792 | 0.87 | AKR1B1 (0.81) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL1247918 | 0.87 | AKR1B1 (0.81) | ADAMTS5AKR1B1PIM1PIM2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070065472-A1 | Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers | L'OREAL (FR) | 2007-03-22 | — | — | US | disclosed |
| US-20070059260-A1 | Benzyl-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening | L'OREAL (FR) | 2007-03-15 | — | — | US | disclosed |
| US-20070059265-A1 | Benzylidene-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss and/or for increasing the density of keratin fibers | L'OREAL (FR) | 2007-03-15 | — | — | US | disclosed |
| US-20070059265-A1 | Benzylidene-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss and/or for increasing the density of keratin fibers | L'OREAL (FR) | 2007-03-15 | — | — | US | disclosed |
| EP-1738742-A2 | Benzyl-1,3-thiazolidine-2,4-dione compounds, compositions comprising them and use for stimulating or inducing the growth of keratinic fibres and/or for diminsihing their loss | L'Oréal (FR) | 2007-01-03 | — | — | EP | disclosed |
| EP-1738740-A2 | Use of benzyl-1,3-thiazolidine-2,4-dione compounds for favouring and/or inducing and/or stimulating the pigmentation of keratinic materials and/or for limiting their depigmentation and/or their bleaching | L'Oréal (FR) | 2007-01-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070059260-A1 | Benzyl-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening | KRT18, TYR, MITF | ADAMTS5 1014/4885AKR1B1 2052/4885PIM1 3552/4885 |
| US-20070059265-A1 | Benzylidene-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss and/or for increasing the density of keratin fibers | KRT18, FGF1, SMO | ADAMTS5 910/4885AKR1B1 1173/4885PIM1 3592/4885 |
| US-20070065472-A1 | Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers | KRT18, FGF1, BRD7 | ADAMTS5 731/4885AKR1B1 1692/4885PIM1 3624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.