Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114587 | 0.82 | KCNH2 (0.42) | SMN1; SMN2HTTGAANPSR1SCD | |
| SCHEMBL1150251 | 0.76 | KCNH2 (0.49) | SMN1; SMN2GAANPSR1LIPGMAPT | |
| SCHEMBL5252805 | 0.74 | L3MBTL1 (0.42) | SMN1; SMN2HTTGAALIPGMAPT | |
| SCHEMBL5127735 | 0.73 | KCNE1 (0.44) | SMN1; SMN2HTTGAANPSR1LMNA | |
| SCHEMBL5119878 | 0.72 | KCNH2 (0.41) | SMN1; SMN2HTTGAANPSR1MAPT | |
| SCHEMBL14610362 | 0.72 | ERCC1 (0.39) | SMN1; SMN2GAANPSR1MAPTSCD | |
| SCHEMBL14470263 | 0.71 | GAA (0.44) | SMN1; SMN2HTTGAANPSR1LIPG | |
| SCHEMBL5113435 | 0.70 | TRPV1 (0.47) | GAAMAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL5526067 | 0.70 | LIPG (0.44) | SMN1; SMN2HTTGAANPSR1LIPG | |
| SCHEMBL5248875 | 0.69 | RXFP1 (0.40) | MAPTLMNATP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-B1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-02-28 | — | — | EP | claimed |