Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2515234 | 0.86 | TSHR (0.65) | SMN1; SMN2MAPTALDH1A1HTTHSD17B10 | |
| SCHEMBL34672 | 0.85 | ALDH1A1 (0.66) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| SCHEMBL5561006 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| Lithium Ion SCHEMBL22638688 | 0.83 | CA1 (0.61) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| SCHEMBL2517845 | 0.83 | MAPT (0.55) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| SCHEMBL4639473 | 0.83 | CA2 (0.59) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| SCHEMBL6855109 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| SCHEMBL65856 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| SCHEMBL13545219 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTALDH1A1HTTLMNA | |
| SCHEMBL3642059 | 0.80 | CA12 (0.59) | SMN1; SMN2MAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748980-A1 | PYRROLIDINE DERIVATIVES AS CB1-RECEPTOR ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005115977-A1 | PYRROLIDINE DERIVATIVES AS CB1-RECEPTOR ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 2005-12-08 | — | — | WO | disclosed |