Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13543237 | 0.81 | HTT (0.66) | SMN1; SMN2MAPTHSD17B10ALDH1A1LMNA | |
| SCHEMBL5249012 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTTRPV4HSD17B10ALDH1A1 | |
| SCHEMBL13543249 | 0.80 | MEN1 (0.62) | SMN1; SMN2MAPTHSD17B10ALDH1A1LMNA | |
| SCHEMBL13543262 | 0.79 | MAPT (0.68) | MAPTALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL5561006 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTTRPV4HSD17B10ALDH1A1 | |
| SCHEMBL34672 | 0.79 | ALDH1A1 (0.66) | SMN1; SMN2MAPTHSD17B10ALDH1A1LMNA | |
| SCHEMBL13543242 | 0.79 | LMNA (0.46) | SMN1; SMN2MAPTALDH1A1LMNANPC1 | |
| SCHEMBL13543239 | 0.79 | ENPP2 (0.50) | — | |
| SCHEMBL10001214 | 0.78 | CA9 (0.69) | SMN1; SMN2ALDH1A1LMNAABCC9ABCC8 | |
| SCHEMBL23091236 | 0.77 | LMNA (0.39) | MAPTALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |