Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | DDT | P30046 | 3/20 | 0.39 |
| ▸ | ULK1 | O75385 | 2/20 | 0.39 |
| ▸ | GLS | O94925 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | BCL9 | O00512 | 2/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3111267 | 0.92 | GLS (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5247497 | 0.91 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5246077 | 0.91 | MMP13 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5246041 | 0.89 | MIF (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5248109 | 0.89 | EGLN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5244307 | 0.88 | DDT (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5250510 | 0.88 | DDT (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5248520 | 0.88 | DDT (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5244881 | 0.87 | GLS (0.49) | GLSROCK2ROCK1 | |
| SCHEMBL5247215 | 0.87 | DDT (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867331-A1 | TRIAZOLE DERIVATIVE AND THE USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-12-19 | — | — | EP | disclosed |