Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 3/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.36 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567350 | 0.84 | ROCK1 (0.44) | ROCK1NPSR1L3MBTL1MAPTKDM4E | |
| SCHEMBL3417296 | 0.78 | ALDH1A1 (0.39) | ROCK1L3MBTL1MAPTKDM4ECYP2A6 | |
| SCHEMBL8303440 | 0.78 | ROCK1 (0.50) | ROCK1NPSR1L3MBTL1MAPTKDM4E | |
| SCHEMBL22320232 | 0.76 | ROCK1 (0.46) | ROCK1NPSR1L3MBTL1MAPTKDM4E | |
| SCHEMBL5250336 | 0.74 | MAPT (0.40) | ROCK1NPSR1L3MBTL1MAPTKDM4E | |
| SCHEMBL1254005 | 0.73 | ROCK1 (0.49) | ROCK1NPSR1L3MBTL1MAPTKDM4E | |
| SCHEMBL8299998 | 0.73 | ROCK1 (0.46) | ROCK1NPSR1L3MBTL1MAPTKDM4E | |
| SCHEMBL2824862 | 0.71 | ROCK1 (0.53) | ROCK1NPSR1L3MBTL1MAPTKDM4E | |
| SCHEMBL8295552 | 0.70 | ROCK1 (0.56) | ROCK1NPSR1L3MBTL1MAPTKDM4E | |
| SCHEMBL6984802 | 0.70 | MAPT (0.54) | ROCK1NPSR1L3MBTL1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861384-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006100502-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | STERIX LIMITED (GB) | 2006-09-28 | — | — | WO | disclosed |