Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | AHR | P35869 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440301 | 0.91 | MEN1 (0.60) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL5252367 | 0.89 | MEN1 (0.71) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL28284502 | 0.85 | LMNA (0.65) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL6797385 | 0.85 | ROCK1 (0.60) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL22453121 | 0.84 | ABCG2 (0.53) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL5078978 | 0.84 | MEN1 (0.79) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL2686638 | 0.82 | MAPK1 (0.55) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL5083062 | 0.82 | RAB9A (0.72) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL6332639 | 0.81 | MEN1 (0.60) | LMNAMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL2714471 | 0.81 | LMNA (0.70) | LMNAMAPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1770093-A1 | Pyrido¬2,3-d|pyrimidine derivatives as phosphodiesterase inhibitors | Roche Palo Alto LLC (US) | 2007-04-04 | — | — | EP | disclosed |
| EP-0631580-A1 | PYRIDO 2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-01-04 | — | — | EP | disclosed |
| WO-1993019068-A1 | PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-09-30 | — | — | WO | disclosed |