Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | PPIA | P62937 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252367 | 0.92 | MEN1 (0.71) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL5250412 | 0.91 | LMNA (0.65) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL22453121 | 0.90 | ABCG2 (0.53) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL6332639 | 0.86 | MEN1 (0.60) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL7272758 | 0.86 | KMT2A (0.60) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL6797385 | 0.85 | ROCK1 (0.60) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL22452840 | 0.85 | MEN1 (0.58) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL2686638 | 0.85 | MAPK1 (0.55) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL7271426 | 0.85 | MEN1 (0.58) | MEN1KMT2AMAPK1PKMHTT | |
| SCHEMBL7281318 | 0.85 | MEN1 (0.81) | MEN1KMT2AMAPK1PKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037345-A | Method for inhibiting neoplastic cells and related conditions by exposure to quinazolinedione and pyridopyrimidinedione derivatives | CELL PATHWAYS, INC. (US) | 2000-03-14 | — | — | US | disclosed |
| CN-1014992-B | QUINAZOLIDIONE AND PYRIDOPYRIMIDINE DIONE AND PREPARING METHOD | PFIZER (US) | 1991-12-04 | — | — | CN | disclosed |
| EP-0260817-B1 | QUINAZOLINEDIONES AND PYRIDOPYRIMIDINEDIONES | PFIZER INC. (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4880810-A | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1989-11-14 | — | — | US | disclosed |
| US-4797403-A | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0260817-A1 | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1988-03-23 | — | — | EP | disclosed |
| CN-87105791-A | Quinazoline diones and Pyridopyrimidine diketone and preparation method thereof | — | 1988-03-09 | — | — | CN | disclosed |
| WO-1988001270-A1 | PYRIDOPYRIMIDINEDIONES | PFIZER INC. (US) | 1988-02-25 | — | — | WO | disclosed |