Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CALCA | P06881 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14609943 | 0.93 | KCNH2 (0.41) | GAANPSR1ERCC1FEN1ERCC4 | |
| SCHEMBL5119878 | 0.92 | KCNH2 (0.41) | GAANPSR1ERCC1FEN1ERCC4 | |
| SCHEMBL5128506 | 0.89 | KCNE1 (0.43) | GAANPSR1ERCC1FEN1ERCC4 | |
| SCHEMBL14609899 | 0.88 | CYP2C9 (0.42) | GAANPSR1ERCC1FEN1ERCC4 | |
| SCHEMBL5128461 | 0.87 | MEN1 (0.42) | NPSR1ERCC1FEN1ERCC4KCNH2 | |
| SCHEMBL5120394 | 0.86 | CALCA (0.41) | GAANPSR1ERCC1FEN1ERCC4 | |
| SCHEMBL5115008 | 0.83 | KCNE1 (0.44) | NPSR1ERCC1FEN1ERCC4KCNH2 | |
| SCHEMBL5117833 | 0.81 | ALDH1A1 (0.42) | NPSR1ERCC1FEN1ERCC4KCNH2 | |
| SCHEMBL5250292 | 0.80 | KCNE1 (0.41) | GAANPSR1ERCC1FEN1ERCC4 | |
| SCHEMBL5114587 | 0.79 | KCNH2 (0.42) | GAANPSR1ERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-B1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-02-28 | — | — | EP | claimed |