SCHEMBL5250544

SCHEMBL5250544

CN(F)C(F)(F)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 3/20 0.48
TSHR P16473 2/20 0.48
ALDH1A1 P00352 2/20 0.48
PTPN1 P18031 1/20 0.38
NR1H2 P55055 2/20 0.38
OPRM1 P35372 1/20 0.37
OPRL1 P41146 1/20 0.37
MAPK1 P28482 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA5A P35218 1/20 0.37
CA9 Q16790 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
NR1H3 Q13133 3/20 0.36
KIF11 P52732 1/20 0.36
CYP2D6 P10635 2/20 0.35
CYP2C19 P33261 1/20 0.35
HSD17B10 Q99714 1/20 0.35
CYP3A4 P08684 1/20 0.35
APOBEC3G Q9HC16 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1336610 0.82 KCNN4 (0.56) KCNN4TSHRALDH1A1PTPN1OPRM1
SCHEMBL3972409 0.79 TSHR (0.52) KCNN4TSHRALDH1A1PTPN1MAPK1
SCHEMBL8800379 0.75 TSHR (0.48) KCNN4TSHRALDH1A1PTPN1MAPK1
SCHEMBL812047 0.71 ALDH1A1 (0.44) KCNN4TSHRALDH1A1PTPN1NR1H2
SCHEMBL3223142 0.71 ALDH1A1 (0.44) KCNN4TSHRALDH1A1PTPN1NR1H2
Trifluoromethylbenzene SCHEMBL11134163 0.69 TSHR (0.78) KCNN4TSHRALDH1A1PTPN1OPRM1
SCHEMBL6342232 0.67 ALDH1A1 (0.58) KCNN4TSHRALDH1A1PTPN1MAPK1
Trifluoromethylbenzene SCHEMBL21879063 0.67 TSHR (0.88) KCNN4TSHRALDH1A1PTPN1OPRM1
SCHEMBL17885872 0.67 ALDH1A1 (0.58) KCNN4TSHRALDH1A1PTPN1MAPK1
SCHEMBL3621303 0.67 ALDH1A1 (0.58) KCNN4TSHRALDH1A1PTPN1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070286783-A1 METHOD OF DEACIDIZING A GASEOUS EFFLUENT WITH EXTRACTION OF THE PRODUCTS TO BE REGENERATED CARRETTE PIERRE-LOUIS 2007-12-13 US disclosed
US-6137011-A CATALYTICALLY HYDROGENATINING BISTRIFLUOROMETHYLBENZONITRILE, IN PRESENCE OF RANEY COBALT,ALIPHATIC ETHER, AND AMMONIA TO FORM BISTRIFLUOROMETHYLBENZYL-AMINE BAYER AKTIENGESELLSCHAFT (DE) 2000-10-24 US disclosed