Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401685 | 0.79 | KMT2A (0.36) | HTR2AHRH1MEN1KMT2AGAA | |
| SCHEMBL15152279 | 0.77 | CYP2C19 (0.46) | HTR2AHRH1MEN1KMT2AGAA | |
| SCHEMBL17803383 | 0.76 | TAAR1 (0.48) | TAAR1HTR2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL24885673 | 0.75 | OPRD1 (0.41) | HTR2AHRH1MEN1KMT2AALDH1A1 | |
| SCHEMBL11173715 | 0.75 | MEN1 (0.40) | TAAR1HTR2AHRH1MEN1KMT2A | |
| SCHEMBL11094516 | 0.74 | TAAR1 (0.46) | TAAR1HTR2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11701106 | 0.74 | NR1H2 (0.43) | HTR2AHRH1MEN1KMT2AALDH1A1 | |
| SCHEMBL3931089 | 0.72 | TRPA1 (0.48) | HTR2AHRH1MEN1KMT2AALDH1A1 | |
| Trolamine SCHEMBL21177786 | 0.72 | TAAR1 (0.47) | TAAR1HTR2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7093914 | 0.71 | TAAR1 (0.52) | TAAR1HTR2ASLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598142-A1 | DIPHENYL ETHER COMPOUNDS FOR THE TREATMENT OF LIVER, LUNG DISORDERS, DIABETIC COMPLICATIONS AND CARDIOVASCULAR DISEASES | Orchid Chemicals and Pharmaceuticals Ltd (IN) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012014218-A1 | DIPHENYL ETHER COMPOUNDS FOR THE TREATMENT OF LIVER, LUNG DISORDERS, DIABETIC COMPLICATIONS AND CARDIOVASCULAR DISEASES | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2012-02-02 | — | — | WO | disclosed |