Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 7/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786116 | 0.89 | TRPA1 (0.36) | MAPTKDM4EMAPK1L3MBTL1NPSR1 | |
| SCHEMBL786645 | 0.82 | ABCG2 (0.47) | MAPTL3MBTL1MEN1KMT2ANPSR1 | |
| SCHEMBL786451 | 0.77 | NPC1 (0.41) | ADORA3ADORA1MEN1KMT2APDE4B | |
| SCHEMBL5256614 | 0.76 | ABCG2 (0.44) | MAPTKDM4EMAPK1L3MBTL1MEN1 | |
| SCHEMBL786316 | 0.76 | PDE4B (0.43) | ADORA3SMN1; SMN2PDE4BCYP1A2CYP3A4 | |
| SCHEMBL786879 | 0.75 | ADORA3 (0.40) | MAPTADORA3PDE4BCYP1A2 | |
| SCHEMBL2205769 | 0.72 | RAB9A (0.43) | MAPTKDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL786491 | 0.72 | MEN1 (0.58) | MAPTL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2203919 | 0.71 | COMT (0.35) | MAPTKDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL2204725 | 0.71 | FFAR1 (0.36) | MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318814-B1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2007-05-30 | — | — | EP | disclosed |