Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.72 |
| ▸ | MMP2 | P08253 | 5/20 | 0.70 |
| ▸ | MMP12 | P39900 | 3/20 | 0.69 |
| ▸ | MMP9 | P14780 | 2/20 | 0.66 |
| ▸ | MMP3 | P08254 | 1/20 | 0.60 |
| ▸ | MMP7 | P09237 | 1/20 | 0.60 |
| ▸ | MMP10 | P09238 | 1/20 | 0.60 |
| ▸ | MMP8 | P22894 | 1/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.60 |
| ▸ | MMP14 | P50281 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254772 | 1.00 | ADAM17 (0.72) | ADAM17MMP2MMP12MMP9MMP3 | |
| SCHEMBL5254112 | 0.94 | MMP2 (0.74) | ADAM17MMP2MMP12MMP9MMP3 | |
| SCHEMBL5217457 | 0.94 | MMP2 (0.74) | ADAM17MMP2MMP12MMP9MMP3 | |
| SCHEMBL5255174 | 0.94 | MMP12 (0.67) | ADAM17MMP2MMP12MMP9MMP13 | |
| SCHEMBL5898083 | 0.90 | MMP2 (0.85) | ADAM17MMP2MMP12MMP9MMP3 | |
| SCHEMBL5898090 | 0.90 | MMP2 (0.85) | ADAM17MMP2MMP12MMP9MMP3 | |
| SCHEMBL5898077 | 0.90 | MMP2 (0.85) | ADAM17MMP2MMP12MMP9MMP3 | |
| SCHEMBL5898081 | 0.90 | MMP2 (0.85) | ADAM17MMP2MMP12MMP9MMP3 | |
| SCHEMBL5898075 | 0.90 | MMP2 (0.85) | ADAM17MMP2MMP12MMP9MMP3 | |
| SCHEMBL5866632 | 0.87 | ADAM17 (0.67) | ADAM17MMP2MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558581-A4 | TRIAZOLONE AND TRIAZOLETHIONE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2007-07-25 | — | — | EP | disclosed |
| US-7074810-B2 | Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1558581-A2 | TRIAZOLONE AND TRIAZOLETHIONE DERIVATIVES | Bristol-Myers Squibb Company (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20040116491-A1 | Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-17 | — | — | US | disclosed |
| WO-2004032846-A2 | TRIAZOLONE AND TRIAZOLETHIONE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-22 | — | — | WO | disclosed |