Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254890 | 0.91 | GPR119 (0.51) | GPR119TP53KMT2AKDM4EMAPT | |
| SCHEMBL4898807 | 0.87 | USP30 (0.50) | GPR119KDM4EMAPTTHRBHCAR1 | |
| SCHEMBL18788085 | 0.87 | NR1H2 (0.47) | GPR119KDM4EMAPTTHRBHCAR1 | |
| SCHEMBL5253861 | 0.87 | STS (0.47) | GPR119KMT2AKDM4EMAPTTHRB | |
| SCHEMBL17092750 | 0.86 | KMT2A (0.46) | GPR119KMT2AKDM4EMAPTTHRB | |
| SCHEMBL5258987 | 0.86 | STS (0.47) | GPR119KDM4EMAPTTHRBHCAR1 | |
| SCHEMBL18917677 | 0.85 | GPR119 (0.43) | GPR119TP53KDM4EMAPTTHRB | |
| SCHEMBL17092719 | 0.84 | GPR119 (0.45) | GPR119TP53KMT2AKDM4EMAPT | |
| SCHEMBL3159082 | 0.84 | GPR119 (0.52) | GPR119KDM4EMAPTTHRBHCAR1 | |
| SCHEMBL3358142 | 0.84 | MAPT (0.52) | GPR119KDM4EMAPTTHRBHCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |
| CN-1639152-A | Pyrrole-2, 5-dione derivatives and their use as GSK-3 inhibitors | LILLY CO ELI (US) | 2005-07-13 | — | — | CN | disclosed |