Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255201 | 0.86 | GPR119 (0.51) | MAPTGPR119HCAR1KDM4ETHRB | |
| SCHEMBL4898807 | 0.85 | USP30 (0.50) | MAPTGPR119HCAR1KDM4ETHRB | |
| SCHEMBL5253861 | 0.85 | STS (0.47) | STSMAPTGPR119HCAR1KDM4E | |
| SCHEMBL18788085 | 0.85 | NR1H2 (0.47) | MAPTGPR119HCAR1KDM4ETHRB | |
| SCHEMBL17092750 | 0.84 | KMT2A (0.46) | MAPTGPR119P2RY14HDAC4HCAR1 | |
| SCHEMBL18917677 | 0.83 | GPR119 (0.43) | MAPTGPR119HCAR1KDM4ETHRB | |
| SCHEMBL17092660 | 0.83 | PRKAA2 (0.50) | — | |
| SCHEMBL17092719 | 0.83 | GPR119 (0.45) | MAPTGPR119HDAC4HCAR1KDM4E | |
| SCHEMBL2861894 | 0.83 | SMN1; SMN2 (0.56) | STSMAPTGPR119HCAR1PKM | |
| SCHEMBL3159082 | 0.82 | GPR119 (0.52) | STSMAPTGPR119HCAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |
| CN-1639152-A | Pyrrole-2, 5-dione derivatives and their use as GSK-3 inhibitors | LILLY CO ELI (US) | 2005-07-13 | — | — | CN | disclosed |