SCHEMBL5255673

SCHEMBL5255673

CCOc1cccc(C=O)c1-c1ccccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.47
ALDH1A1 P00352 4/20 0.45
SMN1; SMN2 Q16637 3/20 0.44
HTT P42858 1/20 0.44
L3MBTL1 Q9Y468 3/20 0.43
ERN1 O75460 2/20 0.42
LMNA P02545 4/20 0.41
MAPT P10636 2/20 0.41
ATM Q13315 1/20 0.41
PDK2 Q15119 1/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
APAF1 O14727 1/20 0.38
USP2 O75604 1/20 0.38
GAA P10253 1/20 0.38
THRB P10828 1/20 0.38
CASP1 P29466 1/20 0.38
BRCA1 P38398 1/20 0.38
CASP7 P55210 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1,2-Dichlorobenzene SCHEMBL27565814 0.82 ALDH1A1 (0.61) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1
SCHEMBL5255681 0.79 ERN1 (0.41) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1
SCHEMBL10533695 0.78 TDP1 (0.46) HPGDALDH1A1HTTERN1LMNA
SCHEMBL1749088 0.77 ALDH1A1 (0.48) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1
SCHEMBL2414360 0.77 ALDH1A1 (0.38) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1
SCHEMBL31401930 0.76 ALDH1A1 (0.73) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1
SCHEMBL535646 0.76 ALDH1A1 (0.73) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1
SCHEMBL27565932 0.75 LMNA (0.56) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1
Fluoride SCHEMBL27600467 0.74 ALDH1A1 (0.70) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1
Benzene SCHEMBL28241676 0.74 ALDH1A1 (0.70) HPGDALDH1A1SMN1; SMN2HTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313471-B1 BENZYLIDENE THIAZOLIDINEDIONES AND THEIR USE AS ANTIMYCOTIC AGENTS UCB SA (BE) 2007-04-11 EP disclosed