Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.43 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1299484 | 0.95 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| SCHEMBL1299793 | 0.92 | ERN1 (0.45) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| SCHEMBL23633015 | 0.83 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| SCHEMBL1299934 | 0.82 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HPGDHTTMAPT | |
| SCHEMBL8057338 | 0.82 | MAPT (0.41) | ALDH1A1SMN1; SMN2HPGDLMNAMAPT | |
| SCHEMBL16950947 | 0.82 | LMNA (0.44) | ALDH1A1SMN1; SMN2HPGDLMNAMAPT | |
| SCHEMBL535646 | 0.81 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| SCHEMBL31401930 | 0.81 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| 1,2-Dichlorobenzene SCHEMBL27565814 | 0.81 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2HPGDHTTLMNA | |
| SCHEMBL3785688 | 0.80 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110372537-B | Gemini surfactant containing Schiff base structure and preparation method thereof | 福州大学 | 2021-04-27 | — | — | CN | claimed |
| CN-115867535-B | Substituted benzamides as modulators of TREX1 | 星座制药公司 | 2024-12-17 | — | — | CN | disclosed |
| US-20230233541-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230233541-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230233541-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2023-07-27 | — | — | US | disclosed |
| EP-4157821-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-115867535-A | Substituted benzamides as modulators of TREX1 | 星座制药公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2021243001-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |
| WO-2021243001-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |
| CN-110372537-B | Gemini surfactant containing Schiff base structure and preparation method thereof | 福州大学 | 2021-04-27 | — | — | CN | disclosed |
| US-20100069413-A1 | Pyrimidine and Quinazoline Derivatives | CHRIST ANDREAS D | 2010-03-18 | — | — | US | disclosed |
| US-7674804-B2 | Pyrimidine and quinazoline derivatives as SST5 modulators | HOFFMANN-LA ROCHE INC. (US) | 2010-03-09 | — | — | US | disclosed |
| EP-2152710-A2 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-02-17 | — | — | EP | disclosed |
| US-7645753-B2 | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-01-12 | — | — | US | disclosed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008145524-A2 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-04 | — | — | WO | disclosed |
| US-20080064697-A1 | PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES | HOFFMAN-LA ROCHE INC. | 2008-03-13 | — | — | US | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |
| US-20080045550-A1 | Pyrimidine and quinazoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | US | disclosed |
| US-20060205718-A1 | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233541-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | TREH, BRIX1, GBA1 | ALDH1A1 327/4885SMN1; SMN2 373/4885HPGD 2001/4885 |
| US-20080064697-A1 | PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES | SSTR5, SSTR3, NPY5R | ALDH1A1 1558/4885SMN1; SMN2 3603/4885HPGD 1347/4885 |
| US-20100069413-A1 | Pyrimidine and Quinazoline Derivatives | SSTR5, SSTR3, NPY5R | ALDH1A1 2667/4885SMN1; SMN2 2995/4885HPGD 1390/4885 |
| US-20080045550-A1 | Pyrimidine and quinazoline derivatives | SSTR5, SSTR3, NPY5R | ALDH1A1 2667/4885SMN1; SMN2 2995/4885HPGD 1390/4885 |
| US-20060205718-A1 | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives | SSTR5, SSTR1, SSTR2 | ALDH1A1 934/4885SMN1; SMN2 1968/4885HPGD 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.