Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254028 | 0.88 | SRC (0.34) | SRCEGFRERBB2GAKSLC6A3 | |
| SCHEMBL5257203 | 0.88 | SRC (0.35) | SRCEGFRERBB2IMPDH2IMPDH1 | |
| SCHEMBL5256736 | 0.84 | IMPDH2 (0.48) | SRCEGFRERBB2IMPDH2IMPDH1 | |
| SCHEMBL19889935 | 0.83 | SRC (0.41) | SRCEGFRERBB2IMPDH2IMPDH1 | |
| SCHEMBL19877059 | 0.82 | SRC (0.41) | SRCEGFRERBB2IMPDH2IMPDH1 | |
| SCHEMBL6379684 | 0.79 | SRC (0.50) | SRCEGFRERBB2GAKABL1 | |
| SCHEMBL6381401 | 0.79 | HPGDS (0.54) | SRCEGFRERBB2IMPDH2IMPDH1 | |
| SCHEMBL5254965 | 0.77 | SRC (0.67) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL5251670 | 0.76 | SRC (0.66) | SRCABL1BCR | |
| SCHEMBL6382093 | 0.76 | SLC6A3 (0.46) | SRCEGFRERBB2IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242382-B1 | TRICYCLIC PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-02-07 | — | — | EP | claimed |