Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254882 | 0.82 | SRC (0.50) | SRCHPGDSNQO1ABL1BCR | |
| SCHEMBL5255093 | 0.82 | SRC (0.50) | SRCHPGDSNQO1ABL1BCR | |
| SCHEMBL6382801 | 0.81 | SRC (0.60) | SRCHPGDSABL1BCRKDM4E | |
| SCHEMBL5253283 | 0.78 | SRC (0.74) | SRCABL1BCR | |
| SCHEMBL3272746 | 0.78 | SRC (0.60) | SRCHPGDSNQO1ABL1BCR | |
| SCHEMBL5257280 | 0.77 | KMT2A (0.47) | KDM4EL3MBTL1NPSR1NCOA3MAPT | |
| SCHEMBL19889935 | 0.77 | SRC (0.41) | SRCABL1BCRMAP2K1 | |
| SCHEMBL5256089 | 0.75 | SRC (0.39) | SRCABL1BCR | |
| SCHEMBL5256736 | 0.75 | IMPDH2 (0.48) | SRCHPGDSKDM4E | |
| SCHEMBL19877059 | 0.73 | SRC (0.41) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242382-B1 | TRICYCLIC PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-02-07 | — | — | EP | claimed |