Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CLPP | Q16740 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | AGXT | P21549 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4137065 | 0.85 | KDM4E (0.48) | KDM4ESMN1; SMN2CLPPALDH1A1P2RX7 | |
| SCHEMBL4137157 | 0.81 | ALDH1A1 (0.53) | KDM4EALDH1A1P2RX7MEN1CYP1A2 | |
| SCHEMBL4955350 | 0.78 | LOXL2 (0.44) | KDM4EALDH1A1P2RX7CYP1A2CYP3A4 | |
| SCHEMBL4146686 | 0.75 | KDM4E (0.36) | KDM4EALDH1A1P2RX7CYP1A2CYP3A4 | |
| SCHEMBL4951892 | 0.74 | USP30 (0.35) | KDM4ESMN1; SMN2CLPPALDH1A1P2RX7 | |
| SCHEMBL4134218 | 0.73 | P2RX7 (0.45) | KDM4ESMN1; SMN2ALDH1A1P2RX7TDP1 | |
| SCHEMBL8363902 | 0.72 | KDM4E (0.45) | KDM4ESMN1; SMN2CLPPALDH1A1P2RX7 | |
| SCHEMBL20004077 | 0.71 | KDM4E (0.55) | KDM4ESMN1; SMN2CLPPALDH1A1P2RX7 | |
| SCHEMBL2732426 | 0.70 | KDM4E (0.58) | KDM4ESMN1; SMN2ALDH1A1P2RX7CYP1A2 | |
| SCHEMBL9160595 | 0.70 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1P2RX7TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423391-B8 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | NOVARTIS AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| EP-1423391-B1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | NOVARTIS AG (CH) | 2006-05-17 | — | — | EP | disclosed |
| EP-1423391-A1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | Novartis AG (CH) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003020721-A1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | NOVARTIS AG (CH) | 2003-03-13 | — | — | WO | disclosed |