Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 11/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 2/20 | 0.39 |
| ▸ | TGM1 | P22735 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 6/20 | 0.39 |
| ▸ | CA2 | P00918 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9342191 | 0.84 | CA1 (0.45) | CA1CA2CA12CA9CA4 | |
| SCHEMBL9750004 | 0.84 | CA1 (0.45) | CA1CA2CA12CA9CA4 | |
| SCHEMBL3991912 | 0.80 | TGM2 (0.43) | TGM2THRATHRBF13A1TGM1 | |
| SCHEMBL5259060 | 0.80 | TGM2 (0.43) | TGM2THRATHRBF13A1TGM1 | |
| SCHEMBL21723688 | 0.80 | CA1 (0.45) | CA1CA2CA12CA9CA4 | |
| SCHEMBL7598191 | 0.79 | SLC7A5 (0.44) | LMNACA1CA2CA12CA9 | |
| SCHEMBL7596061 | 0.79 | CYP1A2 (0.43) | LMNACA1CA2FOLH1 | |
| SCHEMBL29588115 | 0.79 | CYP1A2 (0.43) | LMNACA1CA2FOLH1 | |
| SCHEMBL9435308 | 0.78 | TDP1 (0.39) | LMNACA1CA2CA12CA9 | |
| SCHEMBL5252487 | 0.78 | TDP1 (0.39) | LMNACA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789087-A2 | ENGINEERED ANTIBODY FRAGMENT THAT IRREVERSIBLY BINDS AN ANTIGEN | The Regents of the University of California (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2007058725-A2 | ENGINEERED ANTIBODY FRAGMENT THAT IRREVERSIBLY BINDS AN ANTIGEN | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2006033742-A2 | ENGINEERED ANTIBODY FRAGMENT THAT IRREVERSIBLY BINDS AN ANTIGEN | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-03-30 | — | — | WO | disclosed |