Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28766878 | 0.85 | HTT (0.46) | SMN1; SMN2MAPTLMNARIPK1CCNT1 | |
| SCHEMBL28784326 | 0.79 | SOAT2 (0.41) | SMN1; SMN2LMNANPC1RAB9ACCNT1 | |
| SCHEMBL9453146 | 0.74 | SOAT1 (0.58) | CYP2C9CYP2C19CYP2C18SMN1; SMN2LMNA | |
| SCHEMBL11086699 | 0.73 | SOAT1 (0.60) | CYP2C9CYP2C19SMN1; SMN2LMNANPC1 | |
| SCHEMBL2010242 | 0.73 | MAPT (0.56) | SMN1; SMN2MAPTLMNAMAPK1RIPK1 | |
| SCHEMBL543835 | 0.72 | MAPT (0.56) | CYP2C9CYP2C19SMN1; SMN2MAPTLMNA | |
| SCHEMBL4437551 | 0.71 | EIF2AK4 (0.42) | PDE4BMAPTNPC1RAB9AHTT | |
| SCHEMBL4611265 | 0.69 | ALDH1A1 (0.52) | SMN1; SMN2MAPTLMNAMAPK1HTT | |
| SCHEMBL29151107 | 0.69 | MAPT (0.53) | CYP2C9CYP2C19SMN1; SMN2MAPTLMNA | |
| SCHEMBL30745168 | 0.69 | MAPT (0.53) | CYP2C9CYP2C19SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972946-A | 7H-pyrrolo [2, 3-d ] pyrimidine derivatives and their therapeutically acceptable salts, pharmaceutical preparations containing them and process for preparing the active substances | SZOLCSANYI JANOS (HU) | 2007-05-30 | — | — | CN | disclosed |
| EP-1756110-A1 | 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR PRODUCTION THE ACTIVE AGENT | Szolcsanyi, Janos (HU) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105804-A1 | 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR PRODUCTION THE ACTIVE AGENT | SZOLCSANYI JANOS (HU) | 2005-11-10 | — | — | WO | disclosed |