Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 4/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30800770 | 1.00 | TDP1 (0.58) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL5194061 | 0.86 | TDP1 (0.55) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL30074087 | 0.85 | ATM (0.53) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL1972244 | 0.85 | ATM (0.53) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL29362511 | 0.83 | TDP1 (0.60) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL310839 | 0.83 | TDP1 (0.60) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL2891144 | 0.81 | TDP1 (0.58) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL10757303 | 0.81 | ATM (0.58) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL1414035 | 0.81 | ATM (0.58) | TDP1ATMALDH1A1MAPTMAPK1 | |
| SCHEMBL28035706 | 0.80 | TDP1 (0.56) | TDP1ATMALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250084055-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2025-03-13 | — | — | US | disclosed |
| US-12091397-B2 | Dihydroquinolinones for medical treatment | C4 THERAPEUTICS, INC. | 2024-09-17 | — | — | US | disclosed |
| CN-111278816-B | Dihydro quinolinones | C4医药公司 | 2024-03-15 | — | — | CN | disclosed |
| US-RE49698-E1 | Substituted dihydroquinazolines | AIC246 AG & CO. KG (DE) | 2023-10-17 | — | — | US | disclosed |
| US-20230192643-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | US | disclosed |
| US-11401256-B2 | Dihydroquinolinones for medical treatment | C4 THERAPEUTICS, INC. (US) | 2022-08-02 | — | — | US | disclosed |
| EP-3679028-A1 | DIHYDROQUINOLINONES | C4 Therapeutics, Inc. (US) | 2020-07-15 | — | — | EP | disclosed |
| US-20200207733-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | C4 THERAPEUTICS, INC. (US) | 2020-07-02 | — | — | US | disclosed |
| CN-111278816-A | Dihydroquinolinones | C4医药公司 | 2020-06-12 | — | — | CN | disclosed |
| WO-2019043208-A1 | DIHYDROQUINOLINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2019-03-07 | — | — | WO | disclosed |
| EP-0382687-A2 | Benzofused-N-containing heterocycle derivatives | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1990-08-16 | — | — | EP | disclosed |
| US-4783467-A | Tetrahydroimidazoquinazolinone inotropic agents | PFIZER INC. (US) | 1988-11-08 | — | — | US | disclosed |
| EP-0232912-A1 | Hydroxamic acids of 7-oxabicycloheptane substituted ethers | E.R. Squibb & Sons, Inc. (US) | 1987-08-19 | — | — | EP | disclosed |
| US-4654367-A | ANTIALLERGY, ANTIINFLAMMATORY, ANTIPSORIATIC, PROSTAGLANDINS | E. R. SQUIBB & SONS, INC. (US) | 1987-03-31 | — | — | US | disclosed |
| US-4638012-A | 7-oxabicycloheptane α-substituted ketone prostaglandin analogs useful in the treatment of thrombotic disease | E. R. SQUIBB & SONS, INC. (US) | 1987-01-20 | — | — | US | disclosed |
| EP-0205280-A2 | Tetrahydroimidazoquinazolinone cardiac stimulants | Pfizer Limited (GB) | 1986-12-17 | — | — | EP | disclosed |
| US-4623650-A | BACTERICIDES | PFIZER INC. (US) | 1986-11-18 | — | — | US | disclosed |
| EP-0184384-A1 | Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them | PFIZER INC. (US) | 1986-06-11 | — | — | EP | disclosed |
| EP-0052912-B1 | 7-FLUORO-DIBENZO(B,F)THIEPIN DERIVATIVES, THEIR PREPARATION AND RESOLUTION, AND COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1985-02-06 | — | — | EP | disclosed |
| EP-0052912-A1 | 7-Fluoro-dibenzo(b,f)thiepin derivatives, their preparation and resolution, and compositions containing them | MERCK & CO. INC. (US) | 1982-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12091397-B2 | Dihydroquinolinones for medical treatment | CRBN, RBX1, ADRM1 | TDP1 2908/4885ATM 849/4885ALDH1A1 2816/4885 |
| US-20230192643-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | CRBN, RBX1, ADRM1 | TDP1 2908/4885ATM 849/4885ALDH1A1 2816/4885 |
| US-20250084055-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | CRBN, RBX1, ADRM1 | TDP1 2908/4885ATM 849/4885ALDH1A1 2816/4885 |
| US-20200207733-A1 | DIHYDROQUINOLINONES FOR MEDICAL TREATMENT | CRBN, RBX1, ADRM1 | TDP1 2908/4885ATM 849/4885ALDH1A1 2816/4885 |
| US-11401256-B2 | Dihydroquinolinones for medical treatment | CRBN, RBX1, ADRM1 | TDP1 2908/4885ATM 849/4885ALDH1A1 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.