SCHEMBL5259659

SCHEMBL5259659

CON=C(C(=O)OC)c1ccccc1CC=NON=C(C)c1nn(C)c2cc(Oc3ccc(Cl)cc3)ccc12

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 9/20 0.43
KDR P35968 2/20 0.33
HTR3A P46098 2/20 0.33
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5256221 0.80 HIF1A (0.41) HIF1AKDRHTR3AKMT2A
SCHEMBL5256222 0.80 HIF1A (0.41) HIF1AKDRHTR3AKMT2A
SCHEMBL5257827 0.77 HIF1A (0.36) HIF1AKDRHTR3A
SCHEMBL8624971 0.77 HIF1A (0.36) HIF1AKDRHTR3A
SCHEMBL5261817 0.69 KDR (0.38) HIF1AKDRHTR3AKMT2A
SCHEMBL5258634 0.69 KDR (0.38) HIF1AKDRHTR3AKMT2A
SCHEMBL5256224 0.66 KDR (0.33) HIF1AKDR
SCHEMBL23972094 0.63 HIF1A (0.60) HIF1AKMT2A
SCHEMBL5257830 0.62 KDR (0.34) HIF1AKDR
SCHEMBL8622190 0.62 HIF1A (0.33) HIF1AKDRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0844993-B1 PESTICIDAL INDAZOLE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2007-09-26 EP disclosed
EP-0844993-A2 PESTICIDAL INDAZOLE DERIVATIVES Novartis AG (CH) 1998-06-03 EP disclosed
WO-1997007103-A2 PESTICIDAL INDAZOLE DERIVATIVES NOVARTIS AG (CH) 1997-02-27 WO disclosed