SCHEMBL5259685

SCHEMBL5259685

CC(C)(C)C(NC(c1cccc(C(F)(F)F)c1)S(=O)(=O)c1ccc(Br)cc1)C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.43
ADAMTS4 O75173 2/20 0.43
MMP13 P45452 2/20 0.43
DDR1 Q08345 1/20 0.40
CES2 O00748 1/20 0.39
SLC1A3 P43003 1/20 0.38
SLC1A2 P43004 1/20 0.38
MAPT P10636 2/20 0.38
PTGFR P43088 1/20 0.38
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
AVPR2 P30518 1/20 0.37
GPR27 Q9NS67 1/20 0.37
MPO P05164 1/20 0.36
ADAMTS5 Q9UNA0 1/20 0.36
LMNA P02545 3/20 0.36
CNR2 P34972 1/20 0.36
TP53 P04637 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3447127 0.73 KAT6A (0.48) NPSR1MMP13CES2SLC1A3SLC1A2
SCHEMBL6915011 0.72 CYP3A4 (0.45) NPSR1ADAMTS4MMP13CES2MEN1
SCHEMBL5176207 0.71 PPARG (0.44) NPSR1ADAMTS4MMP13CES2SLC1A3
SCHEMBL19732930 0.70 POLB (0.48) NPSR1CES2MAPTMEN1KMT2A
SCHEMBL5740912 0.70 MAPT (0.39) NPSR1ADAMTS4MMP13DDR1CES2
SCHEMBL5740920 0.68 MAPT (0.41) NPSR1ADAMTS4MMP13DDR1CES2
SCHEMBL1634810 0.67 SMN1; SMN2 (0.56) MAPTMEN1KMT2ALMNATP53
SCHEMBL1634808 0.67 SMN1; SMN2 (0.56) MAPTMEN1KMT2ALMNATP53
SCHEMBL14983791 0.66 CES2 (0.53) NPSR1ADAMTS4MMP13CES2MEN1
SCHEMBL30015679 0.66 CES2 (0.55) CES2MAPTMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1836182-A2 HETEROCYCLYLBIPHENYL DERIVATES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS The Institutes for Pharmaceutical Discovery, LLC (US) 2007-09-26 EP disclosed
WO-2006055625-A2 HETEROCYCLYLBIPHENYL DERIVATES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2006-05-26 WO disclosed
EP-1620422-A2 PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B The Institutes for Pharmaceutical Discovery, LLC (US) 2006-02-01 EP disclosed
WO-2004099170-A2 PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO disclosed