Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 14/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667466 | 0.80 | TRPV1 (0.40) | TRPV1KCNA5KMT2ANAMPTMEN1 | |
| SCHEMBL5261177 | 0.79 | SCN9A (0.41) | TRPV1KCNA5KDM4ESMN1; SMN2NSD2 | |
| SCHEMBL5253740 | 0.78 | KCNA5 (0.37) | TRPV1KCNA5KDM4ESMN1; SMN2NSD2 | |
| SCHEMBL6681376 | 0.77 | TRPV1 (0.42) | TRPV1KCNA5NAMPT | |
| SCHEMBL5259278 | 0.77 | HTR6 (0.39) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL5252933 | 0.76 | KCNA5 (0.35) | TRPV1KCNA5KDM4ESMN1; SMN2NSD2 | |
| SCHEMBL5259747 | 0.75 | MEN1 (0.43) | TRPV1KCNA5KMT2AMEN1ALDH1A1 | |
| SCHEMBL5259734 | 0.75 | MEN1 (0.43) | TRPV1KCNA5KMT2AMEN1ALDH1A1 | |
| SCHEMBL5262991 | 0.74 | TRPV1 (0.44) | TRPV1KCNA5 | |
| SCHEMBL5262987 | 0.74 | TRPV1 (0.44) | TRPV1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383750-B1 | UREA DERIVATIVES AS INTEGRIN ALPHA 4 ANTAGONISTS | ALMIRALL LAB (ES) | 2007-09-26 | — | — | EP | claimed |
| EP-1383750-A2 | UREA DERIVATIVES AS INTEGRIN ALPHA 4 ANTAGONISTS | Almirall Prodesfarma, S.A. (ES) | 2004-01-28 | — | — | EP | claimed |
| WO-2002057242-A2 | UREA DERIVATIVES AS INTEGRIN ALPHA 4 ANTAGONISTS | ALMIRALL PRODESFARMA, S.A. (ES) | 2002-07-25 | — | — | WO | claimed |
| EP-1383750-B1 | UREA DERIVATIVES AS INTEGRIN ALPHA 4 ANTAGONISTS | ALMIRALL LAB (ES) | 2007-09-26 | — | — | EP | disclosed |