Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 2/20 | 0.32 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473976 | 0.81 | TTK (0.42) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL30183372 | 0.76 | CDK2 (0.37) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL525783 | 0.74 | RAB9A (0.34) | CDK2CCNA2CDK4CCND3CDK6 | |
| Trifluoroacetic Acid SCHEMBL30183930 | 0.71 | CDK2 (0.36) | CDK2CCNA2CDK4CCND3CDK6 | |
| Trifluoroacetic Acid SCHEMBL30183463 | 0.71 | CDK2 (0.36) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL30183656 | 0.69 | CDK2 (0.41) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL525472 | 0.64 | CCNA2 (0.35) | CDK2CCNA2CDK4CCND3CDK6 | |
| SCHEMBL525980 | 0.64 | RAB9A (0.39) | — | |
| SCHEMBL30183526 | 0.63 | CDK4 (0.42) | CDK2CCNA2CDK4CCND3AURKA | |
| SCHEMBL30183549 | 0.60 | CDK4 (0.38) | CDK2CCNA2CDK4CCND3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |