Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 14/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.39 |
| ▸ | NPC1 | O15118 | 12/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL525783 | 0.83 | RAB9A (0.34) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL12473977 | 0.82 | CYP1A2 (0.33) | ALDH1A1HPGDKDM4ETSHRCYP1A2 | |
| SCHEMBL525472 | 0.70 | CCNA2 (0.35) | — | |
| SCHEMBL525979 | 0.64 | CDK2 (0.37) | — | |
| SCHEMBL526125 | 0.63 | TTK (0.52) | — | |
| SCHEMBL10092915 | 0.63 | CCNA2 (0.40) | — | |
| SCHEMBL10220785 | 0.62 | CCNA2 (0.57) | — | |
| SCHEMBL9940540 | 0.62 | CCNA2 (0.57) | MAPK1 | |
| SCHEMBL18930374 | 0.61 | CYP1A2 (0.40) | ALDH1A1HPGDGLAKDM4ETSHR | |
| SCHEMBL18945552 | 0.61 | CYP1A2 (0.40) | SMN1; SMN2ALDH1A1HPGDGLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |