Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KIF5B | P33176 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255573 | 0.95 | MCHR1 (0.50) | MCHR1KCNH2ADRA1AADRA1BSMN1; SMN2 | |
| SCHEMBL14370282 | 0.84 | ALDH1A1 (0.49) | MCHR1ADRA1AADRA1BSMN1; SMN2MAPT | |
| SCHEMBL5257155 | 0.83 | MCHR1 (0.50) | MCHR1KCNH2ADRA1AADRA1BSMN1; SMN2 | |
| SCHEMBL5257435 | 0.83 | MCHR1 (0.50) | MCHR1KCNH2ADRA1AADRA1BSMN1; SMN2 | |
| SCHEMBL3863267 | 0.82 | KDM4E (0.53) | MCHR1ADRA1AADRA1BSMN1; SMN2MAPT | |
| SCHEMBL1929569 | 0.81 | MAPT (0.58) | SMN1; SMN2MAPTNPC1CYP1A2CYP3A4 | |
| SCHEMBL3860586 | 0.81 | ADRA1A (0.49) | MCHR1ADRA1AADRA1BSMN1; SMN2MAPT | |
| SCHEMBL264564 | 0.79 | LTA4H (0.57) | MCHR1SMN1; SMN2MAPTNPC1CYP1A2 | |
| SCHEMBL5381777 | 0.79 | LTA4H (0.54) | MCHR1SMN1; SMN2MAPTNPC1CYP1A2 | |
| SCHEMBL4027368 | 0.79 | SMN1; SMN2 (0.46) | MCHR1ADRA1AADRA1BSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442025-B1 | PYRIMIDINONES AS MELANIN CONCENTRATING HORMONE RECEPTOR 1 | SMITHKLINE BEECHAM PLC (GB) | 2007-03-07 | — | — | EP | disclosed |