Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.35 |
| ▸ | MCTS1 | Q9ULC4 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1259808 | 0.87 | PTGES (0.36) | PTGESPTGES2GPR119PPARGPPARA | |
| SCHEMBL1260411 | 0.76 | CNR1 (0.43) | CNR1 | |
| SCHEMBL1260967 | 0.69 | KMT2A (0.43) | CNR1 | |
| SCHEMBL1259826 | 0.67 | CYP2C9 (0.42) | CNR1CNR2 | |
| SCHEMBL1260378 | 0.65 | CNR1 (0.49) | CNR1 | |
| SCHEMBL2906434 | 0.64 | HSD11B1 (0.47) | CNR1 | |
| SCHEMBL1632109 | 0.62 | SLC6A2 (0.52) | — | |
| SCHEMBL5180745 | 0.62 | SLC6A2 (0.52) | — | |
| SCHEMBL8745476 | 0.62 | SLC6A2 (0.52) | — | |
| SCHEMBL1806977 | 0.62 | PTPN1 (0.49) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781636-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | Sanofi-Aventis (FR) | 2007-05-09 | — | — | EP | claimed |
| WO-2006024777-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2006-03-09 | — | — | WO | claimed |
| EP-1781636-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | Sanofi-Aventis (FR) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006024777-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2006-03-09 | — | — | WO | disclosed |