Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | EBP | Q15125 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497990 | 0.86 | PRMT5 (0.49) | KCNH2MAPTHPGDALDH1A1PRMT5 | |
| SCHEMBL5257549 | 0.83 | MAPT (0.44) | CHRNB2CHRNA4MAPTHPGDALDH1A1 | |
| SCHEMBL2969839 | 0.82 | PRMT5 (0.54) | KCNH2MAPTHPGDALDH1A1PRMT5 | |
| SCHEMBL1735199 | 0.79 | CHRNB2 (0.74) | CHRNB2CHRNA4KCNH2MAPTHPGD | |
| SCHEMBL3402348 | 0.78 | CHRNB2 (0.56) | CHRNB2CHRNA4MAPTHPGDALDH1A1 | |
| SCHEMBL2969471 | 0.76 | ALDH1A1 (0.52) | MAPTHPGDALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2976365 | 0.74 | MAPT (0.50) | KCNH2MAPTALDH1A1PRMT5WDR77 | |
| SCHEMBL4935255 | 0.73 | CHRNB2 (0.68) | CHRNB2CHRNA4KCNH2MAPTHPGD | |
| SCHEMBL1284065 | 0.73 | CHRNB2 (0.68) | CHRNB2CHRNA4KCNH2MAPTHPGD | |
| SCHEMBL20303777 | 0.72 | CHRNB2 (0.55) | CHRNB2CHRNA4MAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802586-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044823-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2006-04-27 | — | — | WO | disclosed |