Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GCG | P01275 | 1/20 | 0.47 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.44 |
| ▸ | CYP27B1 | O15528 | 2/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.42 |
| ▸ | BCL2 | P10415 | 2/20 | 0.41 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260794 | 0.87 | MEN1 (0.45) | SMN1; SMN2MEN1RAB9AKMT2AGCG | |
| SCHEMBL5260012 | 0.86 | UTS2R (0.53) | SMN1; SMN2MEN1RAB9AKMT2AGPR139 | |
| SCHEMBL5263124 | 0.85 | MEN1 (0.44) | SMN1; SMN2MEN1RAB9AKMT2AGCG | |
| SCHEMBL5266049 | 0.84 | RAB9A (0.60) | SMN1; SMN2MEN1RAB9AKMT2AGPR139 | |
| SCHEMBL5262774 | 0.83 | SLC6A9 (0.54) | SMN1; SMN2MEN1RAB9AKMT2AGPR139 | |
| SCHEMBL5261389 | 0.78 | CNR1 (0.55) | SMN1; SMN2MEN1RAB9AKMT2A | |
| SCHEMBL5262488 | 0.77 | SLC6A9 (0.55) | SMN1; SMN2MEN1RAB9AKMT2AGPR139 | |
| SCHEMBL5373381 | 0.77 | UTS2R (0.55) | SMN1; SMN2MEN1RAB9AKMT2AUTS2R | |
| SCHEMBL5262392 | 0.76 | SLC6A9 (0.53) | SMN1; SMN2MEN1RAB9AKMT2ACYP27B1 | |
| SCHEMBL5261739 | 0.75 | NPC1 (0.61) | RAB9AGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |