Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 9/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5266049 | 0.86 | RAB9A (0.60) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL5262774 | 0.84 | SLC6A9 (0.54) | UTS2RRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5261415 | 0.84 | P2RX7 (0.46) | UTS2RRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5264039 | 0.84 | KMT2A (0.53) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL5260012 | 0.82 | UTS2R (0.53) | UTS2RRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5367653 | 0.80 | P2RX7 (0.49) | UTS2RRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5263996 | 0.79 | CYP24A1 (0.59) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL16866256 | 0.79 | GAA (0.68) | RAB9ASMN1; SMN2KMT2AOPRM1OPRD1 | |
| SCHEMBL5261739 | 0.79 | NPC1 (0.61) | RAB9ANPC1 | |
| SCHEMBL5262488 | 0.78 | SLC6A9 (0.55) | UTS2RRAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |