Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CBX7 | O95931 | 2/20 | 0.37 |
| ▸ | CDYL2 | Q8N8U2 | 2/20 | 0.37 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.37 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428855 | 0.89 | ALOX12 (0.39) | TSHRHTTALDH1A1ALOX12KMT2A | |
| SCHEMBL5260069 | 0.89 | TSHR (0.46) | TSHRHTTALDH1A1ALOX12KMT2A | |
| SCHEMBL430467 | 0.78 | HTR1A (0.40) | HTTALDH1A1ALOX12KMT2AMEN1 | |
| SCHEMBL430198 | 0.75 | HTR1A (0.38) | HTTALDH1A1ALOX12KMT2AMEN1 | |
| SCHEMBL4971237 | 0.75 | TSHR (0.50) | TSHRHTTALDH1A1ALOX12KMT2A | |
| SCHEMBL30808661 | 0.72 | KMT2A (0.68) | TSHRHTTALDH1A1ALOX12KMT2A | |
| SCHEMBL4970176 | 0.72 | KMT2A (0.68) | TSHRHTTALDH1A1ALOX12KMT2A | |
| SCHEMBL427787 | 0.70 | HTR1A (0.46) | ALDH1A1LMNAHTR1AHTR1DHTR1B | |
| SCHEMBL428166 | 0.69 | TP53 (0.44) | TSHRALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL430548 | 0.68 | THRB (0.38) | KMT2AMEN1HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786822-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024517-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |