Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8147796 | 1.00 | LMNA (0.44) | LMNASTAT1UCHL1NPSR1KDM4E | |
| SCHEMBL583356 | 0.90 | NPSR1 (0.48) | LMNASTAT1UCHL1NPSR1KDM4E | |
| SCHEMBL2535567 | 0.85 | LMNA (0.56) | LMNASTAT1NPSR1KDM4EMAPT | |
| SCHEMBL3743887 | 0.83 | BTK (0.44) | UCHL1BTKERCC5FEN1CYP19A1 | |
| SCHEMBL11878964 | 0.82 | LMNA (0.45) | LMNASTAT1NPSR1KDM4EMAPT | |
| SCHEMBL12993596 | 0.80 | UCHL1 (0.45) | LMNAUCHL1NPSR1KDM4EMAPT | |
| SCHEMBL9874767 | 0.79 | DHODH (0.58) | LMNANPSR1KDM4EMAPTGAA | |
| SCHEMBL11789499 | 0.78 | NPSR1 (0.50) | LMNASTAT1NPSR1KDM4EMAPT | |
| SCHEMBL2794177 | 0.77 | BTK (0.39) | UCHL1NPSR1MAPTBTKERCC5 | |
| SCHEMBL14026969 | 0.77 | UCHL1 (0.41) | LMNAUCHL1NPSR1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043998-B1 | USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-03-07 | — | — | EP | disclosed |
| US-6107305-A | Use of pyrazolo [3,4-b] pyridine as cyclin dependent kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-08-22 | — | — | US | disclosed |