Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778693 | 0.81 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL10151333 | 0.78 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL17352418 | 0.78 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL17352352 | 0.75 | EPHX2 (0.58) | LMNASMN1; SMN2ALDH1A1EPHX2L3MBTL1 | |
| SCHEMBL1073954 | 0.73 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL5385637 | 0.73 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL8968921 | 0.73 | ALDH1A1 (0.51) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL12344538 | 0.73 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| SCHEMBL14573044 | 0.73 | EPHX2 (0.53) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 | |
| Hydrochloric Acid SCHEMBL1073730 | 0.71 | SMN1; SMN2 (0.52) | LMNASMN1; SMN2ALDH1A1EPHX2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836161-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006085149-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-08-17 | — | — | WO | disclosed |